Laboratory Research

Our basic research faculty study a wide range of dermatological disorders. Skin cancers play a prominent role in many research focuses, with a major focus on Melanoma development and progression (Ahmad, Longley, Mukhtar, Setaluri, Wood).  Cutaneous T-Cell Lymphomas (Wood) and Blastic Plasmacytoid Dendritic Cell Neoplasm (Longley) are also important skin cancers under investigation. Research involving non-cancer skin diseases also are important to our research program, including Psoriasis (Mukhtar), depigmentation (Longley), and skin discoloration (Longley).  Research targets range from cellular mechanisms of disease progression and drug resistance (Setaluri)  to patient presentation in a clinical setting. Finally, in addition to traditional treatments, our researchers investigate new uses for current drugs such as anti-inflammatories (Mukhtar), as well as the use of plant-based chemicals for chemoprevention (Ahmad, Mukhtar).

Our world-renowned researchers are supported by grants from the Dermatology Foundation, the National Institutes of Health, the Department of Veterans Affairs, the Department of Defense and several other non-profit organizations and companies.

Nihal Ahmad Head Shot
Nihal Ahmad, PhD - Email

Professor and Associate Vice Chair for Research
Dermatology Research Laboratories

Research Summary
The long-term goal of Ahmad laboratory is to be able to make an impact on the quality of human life through cutting-edge biomedical research. To achieve this goal, we want to define the critical molecular and biochemical events in the process of cancer development that will help us identify the targets for disease management. Using this knowledge, we want to be able to develop new approaches and strategies, which could ultimately be translated from the bench to the bedside, for the prevention and/or treatment of cancer. Thus, our research is focused on two broad and complimentary research areas; 1) cancer biology, and 2) prevention and experimental therapeutics of cancer.

Hao Chang
Hao Chang, PhD - Email

Assistant Professor
Dermatology Research Laboratories

Research Summary
Developmental Genetics of Planar Cell Polarity in Mammalian Skin

Research in my lab focuses on understanding the developmental mechanisms that pattern cells in tissue planes and body axes, a phenomenon known as planar cell polarity (PCP). Mutations in PCP genes have been found to cause many diseases in human patients and/or in mouse models, such as neural tube closure defects, polycystic kidney disease, axon guidance defects and cleft palate. Using mouse skin as a model system, we are interested in dissecting the mechanisms of mammalian PCP and helping us better understand the development of PCP-related diseases.

 

Longley_Jack headshot
B. Jack Longley, MD - Email

Professor and Vice Chair for Dermatopathology
UW Dermatology

Mukhtar_Hasan headshot
Hasan Mukhtar, PhD - Email

Professor and Vice Chair for Research
Dermatology Research Laboratories

Research Summary
The major focus of Mukhtar laboratory is to establish molecular target based approaches for prevention and treatment of cancer and skin disease psoriasis by phytochemicals.

Schieke
Stefan M. Schieke, MD - Email

Assistant Professor
Dermatology Research Laboratories

Research Summary
The Schieke lab studies molecular mechanisms and pathways regulating the functional diversity of cells in tumors and normal tissues. Our research focus areas are phenotypic and functional heterogeneity, metabolic requirements of cell proliferation, and mitochondrial signaling. Understanding the functionally diverse cell states and their impact on disease development and progression will ultimately help to define novel drug targets and molecular therapeutics.

setaluri_vijayasaradhi headshot
Vijayasaradhi Setaluri, PhD - Email

Professor
Dermatology Research Laboratories

Research Summary
My laboratory is interested in understanding molecular mechanisms of skin cancer melanoma tumorigenesis and progression, and basic cell and molecular biology of epidermal melanocytes.
Gary S Wood Headshot
Gary S. Wood, MD - Email

Chairman

Research Summary
The Wood lab group focuses on the pathogenesis and treatment of cutaneous lymphomas and melanomas with special emphasis on apoptotic and proliferative mechanisms.