Vijayasaradhi Setaluri, PhD


Contact: Dermatology Research Laboratories

Phone: 608-263-5362 ·  Email

setaluri_vijayasaradhi headshot

PhD Biochemistry, Hyderabad, India , 1986

Fellowship/Postdoctoral Training
Immunology and Cell Biology of Melanoma, 1992
Memorial Sloan-Kettering Cancer Center, New York

Research Summary
My laboratory is interested in understanding molecular mechanisms of skin cancer melanoma tumorigenesis and progression, and basic cell and molecular biology of epidermal melanocytes.

Recent Publications:

Kedlaya, R., Kandala, G., Liu, T. F., Maddodi, N., Devi. S., and Setaluri, V. (2011) Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes Archives of Biochemistry and Biophysics, 508: 227-233.

Syed, D. N., Afaq, F., Maddodi, N., Johnson, J. J., Sarfaraz, S., Ahmad. A., Setaluri, V., and Mukhtar, H (2011) Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels. Journal of Investigative Dermatology Epub. Feb 24

Goswami, S., Tarapore, R. S., Teslaa, J. J., Grinblat, Y., Setaluri, V., and Spiegelman, V. S. (2010) MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein. Journal of Biological Chemistry, 285: 20532-20540.

Maddodi, N. and Setaluri, V. (2010) Prognostic significance of melanoma differentiation and transdifferentiation. Cancers 2: 989-999

Xu, X., Kedlaya, R., Ikeda, S., Justice, M. J., Setaluri, V., and Ikeda, A. (2010) Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. PLoS Genetics 6: e1000956

Maddodi, N., Huang, W., Havighurst, T., Kim, K., Longley, J., and Setaluri, V. (2010) Hyperactivation of Oncogenic BRAF Triggers Autophagy and Inhibits Melanoma Tumor Growth in vitro and in vivo. Journal of Investigative Dermatology. 130:1657-1667.

Maddodi, N., Bhat, K. M. R., Devi, S., Zhang, S-C., and Setaluri, V. (2010) Oncogenic BRAFV600E Induces Expression of Neuronal Differentiation Marker MAP2 in Melanoma Cells by Promoter Demethylation and Downregulation of Transcriptional Repressor HES1. Journal of Biological Chemistry 285:242-54

Devi, S., Kedlaya, R., Maddodi, N., Bhat, K. M. R., Weber, C. S., Valdivia, H., and Setaluri, V. (2009) Calcium homeostasis in human melanocytes: Role of transient receptor potential melastatin 1 (TRPM1) and its regulation by Ultraviolet Light. American Journal of Physiology-Cell Physiology 297: C679-687.

Schmit, T. L., Zhong, W., Setaluri, V., Spiegelman, V. S, and Ahmad, N. (2009) Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. Journal of Investigative Dermatology 129:2843-2853.

Bin Hafeez, B., Adhami, V. M., Asim, M., Siddiqui, I. A., Bhat, K. M., Zhong, W., Saleem, M., Din, M., Setaluri, V., Mukhtar, H. (2009) Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clinical Cancer Research 15: 452-459.

Maddodi, N., Setaluri, V. (2008) Role of UV in Cutaneous Melanoma. Photochemistry and Photobiology 84:528-536