Daniel Greenspan, PhD
Professor, Cell & Regenerative Biology
University of Wisconsin
“BMP1-like proteinases are essential to the structure and wound healing of skin”
Monday, July 25, 2016
Dan Greenspan obtained his bachelors degree with dual majors in Biology and English Literature from New York University. He then went on to earn an M.S. and Ph.D. in the Department of Pathology at NYU School of Medicine, where he studied the phosphorylation control of SV40 large T antigen and its interactions with P53, in the lab of Robert Carroll. He then did a postdoctoral fellowship in the Department of Human Genetics at Yale School of Medicine, studying HLA genes and RNA splicing under the supervision of Sherman Weissman. Dan began here at the UW as a faculty member in the Department of Pathology and Laboratory Medicine, in which he was Assistant, Associate, and then full Professor. While there he was the recipient of the Kellett Mid-career Award from the UW and the Wisconsin Alumni Research Foundation, and was Vice Chair for Research for the Department for a number of years. He joined the Department of Cell and Regenerative Biology when it was formed, and was interim chair of that Department for the first four years of its existence.
Since coming to Madison, Dan’s lab initially focused on discovery of new components of the extracellular matrix and their relation to human disease, and collaborated in studies that showed a collagen V gene to be the locus in which mutations can cause the hereditary skin-related disease classic Ehlers-Danlos syndrome, and showed the collagen VII gene to be the locus in which mutations can cause the lethal hereditary skin disease dystrophic epidermolysis bullosa. His lab has since focused on extracellular regulatory proteins that control and orchestrate events as diverse as growth factor signaling and formation of the extracellular matrix. One of the seminal findings of Dan’s lab was the discovery that bone morphogenetic protein 1 is a proteinase responsible for the biosynthetic processing of precursor procollagen molecules into the building blocks of collagen fibrils, the major structural components of vertebrate tissues.
Image and bio courtesy of Dr. Greenspan
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