Vaqar Adhami, PhD
Mukhtar Laboratory Page
All Inquiries: Research and Administration
BS (Biology/Chemistry) 1986, Kashmir University, India
MS (Zoology) 1989, Aligarh Muslim University, Aligarh, India
Diploma (Medical Lab Technology and Clinical Pathology) 1991, Aligarh University, Aligarh, India
PhD (Toxicology & Medical Elementology) 1998; Industrial Toxicology Research Center and Hamdard University, New Delhi
2000-2002: Postdoctoral Fellow, Dermatology, Case Western Reserve University
1994-1997: Senior Research Fellow, Industrial Toxicology Research Center, Lucknow
1992-1994: Junior Research Fellow, Industrial Toxicology Research Center, Lucknow
During the last ten years I have devoted greater part of my efforts in understanding how commonly used dietary ingredients can be exploited in the prevention and treatment of cancers such as those of skin and prostate. Understanding how these agents modify cellular function is both exciting as well as important in devising effective preventive strategies against cancer.
My previous observations show that polyphenolic fraction isolated from green tea inhibits the IGF-I signaling and acts as anti-inflammatory agent against skin and prostate cancers. In addition I have also observed that the limitations of using COX-2 inhibitors for chemoprevention can be overcome when using them at low doses and in combination with physiologically achievable doses of green tea.
My long term objectives and goals are to establish molecular targets for prevention of skin and prostate cancers and to continue chemopreventive studies of other dietary substances.
Khan MI, Rath S, Adhami VM, Mukhtar H. Hypoxia Driven Glycation: Mechanisms and Therapeutic Opportunities. Semin Cancer Biol. 2017 May 22. [Epub ahead of print] Review. PMID: 28546110.
Khan MI, Rath S, Adhami VM, Mukhtar H. Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges. Pharmacol Res. 2018 Mar;129:375-387. PMID: 29233676.
Sanna V, Singh CK, Jashari R, Adhami VM, Chamcheu JC, Rady I, Sechi M, Mukhtar H, Siddiqui IA. Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy. Sci Rep. 2017 Feb 1;7:41573. PMID: 28145499.
Mukhtar E, Adhami VM, Siddiqui IA, Verma AK, Mukhtar H. Fisetin enhances chemotherapeutic effect of cabazitaxel against human prostate cancer cells. Mol Cancer Ther. 2016 Dec;15(12):2863-2874. PMID: 27765854.
Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodriquez MI, Longley BJ, Wood GS, Mukhtar H. Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. Antioxid Redox Signal. 2017 Jan 10;26(2):49-69. PMID: 27393705.
Lall RK, Syed DN, Khan MI, Adhami VM, Gong Y, Lucey JA, Mukhtar H. Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis. Carcinogenesis. 2016 Sep;37(9):918-28. PMID: 27335141.
Adhami VM, Mukhtar H. Nutrition in the cause and prevention of cancer: An update. Mol Nutr Food Res. 2016 Jun;60(6):1226-7. PMID: 27276214.
Syed DN, Adhami VM, Khan N, Khan MI, Mukhtar H. Exploring the molecular targets of dietary flavonoid fisetin in cancer. Semin Cancer Biol. 2016 Oct;40-41:130-140. PMID: 27163728.
Lall RK, Adhami VM, Mukhtar H. Dietary flavonoid fisetin for cancer prevention and treatment. Mol Nutr Food Res. 2016 Jun;60(6):1396-405. PMID: 27059089.
Chamcheu JC, Chaves-Rodriquez MI, Adhami VM, Siddiqui IA, Wood GS, Longley BJ, Mukhtar H. Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model. Acta Derm Venereol. 2016 Feb 2. PMID: 26833029.