Position title: Scientist I
Schieke Laboratory Page
All Inquiries: Research and Administration
PhD (Life Science) 2016; Jawaharlal Nehru University, New Delhi, India
MS (Biotechnology) 2010; Aligarh Muslim University, Aligarh, India
BS (Zoology, Botany, Chemistry) 2007; Aligarh Muslim University, Aligarh, India
November 2016 – October 2021: Postdoctoral Research Associate, Department of Dermatology, University of Wisconsin-Madison, WI, USA
2013 – 2016: Senior Research Fellow, CSIR-Central Drug Research Institute, Lucknow, India
2011-2013: Junior Research Fellow, CSIR-Central Drug Research Institute, Lucknow, India
Curriculum Vitae (PDF)
Metabolic reprogramming has been identified as a hallmark of cancer. The rewired metabolic pathways in tumor cells facilitate malignant transformation, enable tumor progression, and help cancer cells to resist therapeutic insult. Identifying reprogrammed pathways in cancer cells will allow us to better understand the biology of cancer and thus uncover new therapeutic opportunities. I use cell biology, metabolomics, and animal models of malignant T cells to study how metabolic rewiring enable malignant cells to escape therapeutic treatments.
Gautam Y, Das S, Khan H, Pathak N, Iqbal H, Yadav P, Sirohi VK, Khan S, Raghuvanshi DS, Dwivedi A, Chanda D, Shanker K, Khan F, Konwar R, Negi AS. Design, synthesis and broad spectrum antibreast cancer activity of diarylindoles via induction of apoptosis in aggressive breast cancer cells. Bioorganic & Medicinal Chemistry. 2021;42:116252.
Khan H and Schieke SM. How to starve cancer cells when nutrients are abundant. Molecular & Cellular Oncology. 2020;7(2):1718475.
Khan H, Anshu A, Prasad A, Roy S, Jeffery J, Kittipongdaja W, Yang DT, Schieke SM. Metabolic rewiring in response to biguanides is mediated by mROS/HIF-1a in malignant lymphocytes. Cell Reports. 2019;29:3009-3018.
Khan BF*, Hamidullah*, Dwivedi S, Konwar R, Zubair S, Owais M. Potential of bacterial culture media in biofabrication of metal nanoparticles and the therapeutic potential of the as-synthesized nanoparticles in conjunction with artemisinin against MDA-MB-231 breast cancer cells. Journal of Cellular Physiology. 2018. doi: 10.1002/jcp.27438. (*Equal contribution).
Saini KS*, Hamidullah*, Ashraf R, Mandalapu D, Das S, Siddiqui MQ, Dwivedi S, Sarkar J, Sharma VL, Konwar R. New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis. Molecular Carcinogenesis. 2017; 56:1266-1280. (*Equal contribution).
Upadhyaya K*, Hamidullah*, Singh K, Arun A, Shukla M, Srivastav N, Ashraf R, Sharma A, Mahar R, Shukla SK, Sarkar J, Ramachandran R, Lal J, Konwar R, Tripathi RP. Identification of Gallic acid based Glycoconjugates as a novel anti-tumor agents targeting tubulin polymerization. Organic & Biomolecular Chemistry. 2015; 14:1338-1358. (*Equal contribution).
Hamidullah, Kumar R, Saini KS, Kumar A, Kumar S, Ramakrishna E, Maurya R, Konwar R, Chattopadhyay N. Quercetin-6-C-β-d-glucopyranoside, natural analog of quercetin exhibits anti-prostate cancer activity by inhibiting Akt-mTOR pathway via aryl hydrocarbon receptor. Biochimie. 2015; 119:68-79.
Hamidullah, Saini KS, Ajay A, Devender N, Bhattacharjee A, Das S, Dwivedi S, Gupt MP, Bora HK, Mitra K, Tripathi RP, Konwar R. Triazole analogue 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagydependent apoptosis in both in vitro and in vivo breast cancer models. The International Journal of Biochemistry & Cell Biology. 2015; 65:275-287.
Devender N*, Ramakrishna KK, Hamidullah*, Shukla SK, Konwar R, Tripathi RP. Synthesis and anticancer activity of γ-(triazolyl ethylidene)butenolides and polyfunctional pyrrolinones. European Journal of Medicinal Chemistry. 2014; 82:106-119. (*Equal contribution)
Hamidullah, Changkija B, Konwar R. Role of interleukin-10 in breast cancer. Breast Cancer Research and Treatment. 2012; 133:11-21