Tony Hsiao, MD, PhD

Position title: Associate Scientist


Portrait of Tony Xiao, MD, PhD

Research Laboratory
Longley Laboratory Page

All Inquiries: Research and Administration

Bachelor of Medicine, 1991, Tongji Medical College, China
MS (Dermatopathology/Molecular Biology), 1998, Tongji Medical College, China
PhD (Biology), 2002, University of Ulm, Germany
MD, 2004, University of Wuerzburg, Germany

2003-2005: Postdoctoral Fellow, Molecular Genetics, National Institute of Environmental Health and Science
2003-2008: Postdoctoral Fellow, Stem Cell Biology, University of California, San Francisco
2008-2009: Postdoctoral Fellow, Skin Cancer, Children’s Hospital Oakland Research Institute/UCSF
2010-2012: NIH T32 Trainee, Cutaneous Biology, University of Wisconsin-Madison

Curriculum Vitai (PDF)

PubMed Publications (external link)

Research Interests

My research focus is to challenge current understanding of physiological and pathological mechanisms of Melanoma Associated AntiGEns in melanocyte and melanoma development. The outcome would lead to novel, target specific therapeutic strategies that affect the treatment of patients with a wide range of cancer types. The unique transgenic MAGE Knock-in mouse model provides solid foundation to explore disease-oriented mechanisms and select and validate potential therapeutic candidates.

Recent Publications

Xiao TZ, Suh Y, Longley BJ. MAGE proteins regulate KRAB zinc finger transcription factors and KAP1 E3 ligase activity. Arch Biochem Biophys. 2014 Dec 1;563:136-44. Epub 2014 Aug 7. PMID: 25107531

Bhatia N, Xiao TZ, Rosenthal KA, Siddiqui IA, Thiyagarajan S, Smart B, Meng Q, Zuleger CL, Mukhtar H, Kenney SC, Albertini MR, Jack Longley B. 2013. MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair. J Invest Dermatol 133: 759-67. PMID: 23096706

Bhatia N, Yang B, Xiao TZ, Peters N, Hoffmann MF, Longley BJ. Identification of novel small molecules that inhibit protein-protein interactions between MAGE and KAP-1. Arch Biochem Biophys. 2011 Apr 15;508(2):217-21. Epub 2011 Jan 28. PMID: 21277283

Xiao TZ, Bhatia N, Urrutia R, Lomberk GA, Simpson A, Longley BJ. MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. PLoS One. 2011;6(8):e23747. Epub 2011 Aug 18. PMID: 21876767


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