Naghma Khan, PhD

Associate Scientist

nkhan@dermatology.wisc.edu

Portrait of Naghma Khan, PhD

Research Laboratory
Mukhtar Laboratory Page

Contact
All Inquiries: Research and Administration

Education
BS (Zoology, Botany, & Chemistry) 1997, University of Delhi, India
MS (Toxicology) 1999, Jamia Hamdard University, New Delhi
PhD (Toxicology) 2004, Jamia Hamdard University, New Delhi

Curriculum Vitae (PDF)

PubMed Publications (external link)

Research Interests

My research goal is to define dietary mechanism-based agents for the prevention/treatment of cancer. This process specifically revolve around identifying dietary agents that show pre-clinical promise using in-vitro and in-vivo models and directing them to a Phase I human clinical trial setting.

At present, through the work funded by the American Cancer Society, I am exploring the roles of mutant PI3K in colorectal cancer growth, survival, and metastasis that will help unveil the mechanisms of malignant progression. My research is focused on developing a dietary, nontoxic agent which can be used as an adjuvant for the prevention and treatment of PI3K-mutant colorectal cancer.

Recent Publications

Khan N*, Jajeh F, Khan MI, Mukhtar E, Shabana SM and Mukhtar H. Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells. Carcinogenesis, 2017, 38: 184-195. PMID: 27881463. *Corresponding author

Syed DN, Adhami VM, Khan N, Khan MI and Mukhtar H. Exploring the molecular targets of dietary flavonoid fisetin in cancer. Seminars in Cancer Biology, 2016, 40-41: 130-140. PMID: 27163728.

Khan N and Mukhtar H. Dietary agents for prevention and treatment of lung cancer. Cancer Letters, 2015, 359: 155-164. PMID: 25644088.

Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, and Mukhtar H. Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a fullthickness three-dimensional reconstituted human skin model of psoriasis. Skin Pharmacology and Physiology, 2015, 28:177-188. PMID: 25620035.

Khan N, Bharali DJ, Adhami VM, Siddiqui IA, Cui H, Shabana SH, Mousa SA and Mukhtar H. Oral administration of naturally occurring chitosan based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis, 2014, 35: 415-423. PMID: 24072771.

Khan N, Syed DN, Ahmad N, and Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxidants & Redox Signaling, 2013, 19:151-162. PMID: 23121441.

Khan N and Mukhtar H. Tea and health: Studies in humans. Current Pharmaceutical Design, 2013, 19: 6141-6147. PMID: 23448443.

Khan N and Mukhtar H. Modulation of signaling pathways in prostate cancer by green tea polyphenols. Biochemical Pharmacology, 2013, 85: 667-672. PMID: 23041649.

Khan N, Adhami VM, Afaq F and Mukhtar H. Butein induces apoptosis and inhibits prostate tumor growth in-vitro and in-vivo. Antioxidants & Redox Signaling, 2012, 16: 1195-204. PMID: 22114764.

Khan N, Afaq F, Khusro FH, Adhami VM, Suh Y and Mukhtar H. Dual inhibition of PI3K/Akt and mTOR signaling in human non-small cell lung cancer cells by a dietary flavonoid fisetin. International Journal of Cancer, 2012, 130: 1695-1705. PMID: 21618507.