Deeba N. Syed, MBBS, PhD
Mukhtar Laboratory Page
All Inquiries: Research and Administration
MBBS (Medicine & Surgery) 1989, Dow Medical College, Karachi, Pakistan
Resident Physician (Medicine) 1990, Dow Medical College, Karachi, Pakistan
Resident Surgeon (Surgery) 1991, Dow Medical College, Karachi, Pakistan
Certification (Biotechnology) 2003, Madison Area College, Madison, WI
PhD (Molecular & Environmental Toxicology) 2011, University of Wisconsin – Madison
2013: Concept award, PanAmerican Society for Pigment Cell Research
2012: Kligman Travel Award, Society of Investigative Dermatology
2009: Trainee Grant, NIAMS T32ES007015
My long term goal is to characterize the cross talk between metabolic pathways and signaling molecules driving aberrant cell growth in cutaneous pathologies which can then assist in stratification of patients for downstream therapeutic decisions.
AlJohani AM, Syed DN, Khan MI, Bonneville A, Mukhtar H, Ntambi JM. Reduced hepatic oleate induces ER stress through mTORC1 (manuscript under preparation for Metabolism).
Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ. Synthetic transcription elongation factors license transcription across repressive chromatin. Science. 2017 Dec 22;358(6370):1617-1622. PMID: 29192133
ALJohani AM, Syed DN, Ntambi JM. Insights into Stearoyl-coA desaturase-1 regulation of systemic metabolism. Trends in Endoc and Metab. 2017. PMID: 29089222
Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodriquez MI, Longley BJ, Wood GS, Mukhtar H. Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. Antioxid Redox Signal. 2017 Jan 10;26(2):49-69. PMID: 27393705.
Syed DN, Mukhtar H. FICZ: A Messenger of Light in Human Skin. J Invest Dermatol. 2015 Jun;135(6):1478-81. PMID:25964268.
Syed DN, Chamcheu JC, Khan MI, Sechi M, Lall RK, Adhami VM, Mukhtar H. Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling. Biochem Pharmacol. 2014 Jun 1;89(3):349-60. PMID: 24675012.
Syed DN, Khan MI, Shabbir M, Mukhtar H. MicroRNAs in skin response to UV radiation. Curr Drug Targets. 2013 Sep;14(10):1128-34. PMID: 23834148.
Syed DN, Afaq F, Mukhtar H. Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes. Photochem Photobiol. 2012 Sep-Oct;88(5):1184-90. PMID: 22335604; PMCID: PMC3445260.
Syed DN, Afaq F, Maddodi N, Johnson JJ, Sarfaraz S, Ahmad A, Setaluri V, Mukhtar H. Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels. J Invest Dermatol. 2011 Jun;131(6):1291-9. PMID: 21346776.
Johnson JJ, Syed DN, Suh Y, Heren CR, Saleem M, Siddiqui IA, Mukhtar H. Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention. Cancer Prev Res. 2010 Sep;3(9):1112-23. PMID: 20736335.