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Laboratory Research

About our labs

Basic research faculty in the Department of Dermatology study a wide range of dermatological disorders, including skin cancers and non-cancer skin diseases such as Psoriasis, depigmentation, and skin discoloration.

Research targets in our labs range from cellular mechanisms of disease progression and drug resistance to patient presentation in a clinical setting, and our researchers are investigating new uses for current drugs such as anti-inflammatories, as well as the use of plant-based chemicals for chemoprevention.

Our world-renowned researchers are supported by grants from the Dermatology Foundation, the National Institutes of Health, the Department of Veterans Affairs, the Department of Defense and several other non-profit organizations and companies.

Research Topics by Lab

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All Labs

Ahmad

  • Melanoma development and progression
  • Use of plant-based chemicals for chemoprevention
  • Role of Plk1 in Cancer
  • Role of SIRT1 in Cancer
  • Chemoprevention of Cancer by Resveratrol

Chang

  • Frizzled6 signaling in hair orientation control
  • Astrotactin2 in PCP and development

Longley

  • Melanoma development and progression
  • Blastic plasmacytoid dendritic cell neoplasm
  • Depigmentation
  • Skin discoloration
  • Establishing mastocytosis as an oncogene driven neoplasia
  • Discovery and characterization of the intracellular-juxtamembrane class of KIT activating mutations
  • Discovery of human epidermal keratinocyte KIT ligand and creation of humanized K14-KIT ligand transgenic mice with epidermal melanocytes

Mukhtar

  • Melanoma development and progression
  • Psoriasis
  • New uses for existing anti-inflammatories
  • Use of plant-based chemicals for chemoprevention
  • Cancer prevention and therapy
  • Prevention of photocarcinogenesis and photoaging
  • Apoptosis by dietary factors: the suicide solution for delaying cancer growth
  • Nanochemoprevention-sustained release of bioactive food components for cancer prevention
  • Cancer biomarkers

Schieke

  • Cutaneous T-cell lymphomas
  • Cellular mechanisms of disease progression and drug resistance
  • Phenotypic plasticity and drug-resistance
  • Metabolic dynamics during cancer progression
  • Targeting the mitochondrial stress response

Setaluri

  • Melanoma development and progression
  • Cellular mechanisms of disease progression and drug resistance
  • Melanocyte biology

Wood

  • Melanoma development and progression
  • Patient presentation in a clinical setting

Labs by Research Topic

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Labs by Topic: Skin Cancer

Melanoma development and progression

Cutaneous T-Cell Lymphomas

Blastic Plasmacytoid Dendritic Cell Neoplasm

Labs by Topic: Non-Cancer Skin Diseases

Psoriasis

Depigmentation

Skin Discoloration

Labs by Topic: Research Target

Cellular mechanisms of disease progression and drug resistance

Patient presentation in a clinical setting

New uses for current anti-inflammatories

Use of plant-based chemicals for chemoprevention

Research Faculty

Nihal Ahmad, PhD

Professor and Vice Chair for Research, Dermatology Research Laboratories

Hao Chang, PhD

Assistant Professor, Dermatology Research Laboratories

B. Jack Longley, MD

Professor and Vice Chair for Dermatopathology, UW Dermatology

Hasan Mukhtar, PhD

Professor and Vice Chair for Research, Dermatology Research Laboratories

Stefan M. Schieke, MD

Assistant Professor, Dermatology Research Laboratories

Vijayasaradhi Setaluri, PhD

Professor, Dermatology Research Laboratories

Gary Wood, MD

Professor and Founding Chair, Geneva F. and Sture Johnson Professor Emeritus