Clinical Research

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Histologic Analysis of Onychomycosis with Clinical Correlations

In this medical record review, we will measure the density of fungus in the nails of patients previously diagnosed with onychomycosis with a software program and correlate this to the clinical severity of onychomycosis. The response to treatment will be used to explore whether the density of fungal infection is an independent predictor of response to treatment. Characterization and assessment of the anatomic location of fungus in biopsies of nails of the same population will be investigated as well, including common subtypes of onychomycosis.

Study Type: Non-Intervention
Category: N/A
Enrollment Status: Not Open to Enrollment

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Utilization of Dermatopathology Laboratory Archival Tissue for Feasibility Research

This protocol allows the use of de-identified diagnostic samples in exploratory or feasibility testing. The University of Wisconsin Hospital and Clinics (UWHC) Dermatopathology laboratory collects and stores residual diagnostic fresh tissue samples, which can be preserved as paraffin-embedded, frozen tissue, or as slides. Upon request the Department of Dermatology can provide investigators with samples of these tissues for exploratory or feasibility testing prior to their application for a separate IRB approved protocol.

Study Type: Non-Intervention
Category: N/A
Enrollment Status: Not Open to Enrollment

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Mechanism for Cancer Development and Progression

This protocol utilizes de-identified human pathological specimens such as begin and cancerous tissues, tissue microarrays (TMAs), established cell lines, primary cells and tissue arrays in ongoing research to understand the mechanisms of cancer development and progression, to identify novel biomarkers and approaches for the management of these diseases.

Study Type: Non-Intervention
Category: Cutaneous Oncology
Enrollment Status: Not Open to Enrollment

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Utilization of Dermatopathology Laboratory Archival Tissue for Feasibility Research

This protocol allows the use of de-identified diagnostic samples in exploratory or feasibility testing. The University of Wisconsin Hospital and Clinics (UWHC) Dermatopathology laboratory and the UW Skin Disease Research Center (SDRC) collects and stores residual diagnostic fresh tissue samples, which can be preserved as paraffin-embedded, frozen tissue, or as slides. Investigators many request samples of these tissues for exploratory or feasibility testing prior to their application for a separate IRB approved protocol or for use with an IRB approved protocol.

Study Type: Non-Intervention
Category: N/A
Enrollment Status: Not Open to Enrollment

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Cutaneous Crohn Disease: Retrospective Review of Clinical Features, Disease Course, Treatment, and Outcomes

This study will better characterize the epidemiology and natural course of cutaneous Crohn disease in the United States with a specific focus on metastatic Crohn disease. It will describe the patient characteristics, the correlation between clinical and histopathologic features, potential disease triggers, long-term patient outcomes (e.g., prevalence and timing of intestinal disease), treatment patterns and response to therapy, complications, and health care utilization. Additionally, this study may provide insight into potential triggers of cutaneous Crohn disease.

Study Type: Non-Intervention
Category: Inflammatory Dermatoses
Enrollment Status: Not Open to Enrollment

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Epidemiology of Chilblains Before & During the COVID-19 Pandemic

The purpose of our study is to describe the incidence and demographics of chilblains visits before and during the pandemic. Additionally, we plan to examine trends among ambient temperature, community infection rates and presentation to health care for pandemic-associated chilblains during the pandemic.

Study Type: Non-Intervention
Category: COVID-19
Enrollment Status: Not Open to Enrollment

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Assessing the Sensitivity and Specificity of Imaging in Cutaneous Squamous Cell Carcinoma to Detect Nodal Metastasis Using Lymph Node Biopsy Results as the Gold Standard

The purpose of our study is to establish the sensitivity and specificity of imaging to detect nodal metastasis in cutaneous squamous cell carcinoma. We aim to evaluate the sensitivity and specificity of imaging modalities in detection of nodal metastasis for cutaneous SCC with use of lymph node biopsy results as the gold standard.

Study Type: Non-Intervention
Category: Cutaneous Oncology
Enrollment Status: Not Open to Enrollment

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Clinical, Immunologic, and Genetic Characterization of Severe Mucocutaneous Reactions

Our goal is to develop a better understanding of the cause of severe blistering skin reactions or related disorders. We hope that by better understanding the cause we may be able to improve care for people who are affected by these skin reactions.

Study Type: Non-Intervention
Category: Skin Reactions
Enrollment Status: Open to Enrollment

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Creation of Benign Nevi and Melanoma Tissue Microarray for Distribution Through the UW Skin Disease Research Center

Our goal is to create and distribute de-identified tissue microarrays consisting of benign growths, usually hyperpigmented or skin-colored macules, papules, or small plaques probably derived from proliferating altered melanocytes (nevus cells) and malignant melanoma. The tissue microarrays will be disturbed, upon approval, to investigators performing skin disease research though the UW Skin Disease Research Center.

Study Type: Non-Intervention
Category: Melanoma
Enrollment Status: Not Open to Enrollment

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Molecular Markers for Melanoma Progression

Cutaneous melanoma is the deadliest form of skin cancer. If diagnosed early and treated appropriately before the cancer becomes aggressive, melanoma is often curable. However, there are no known biological markers to reliably assess the aggressiveness of melanoma. The goal of this project is to assess the value of novel markers in predicting melanoma tumor aggressiveness.

Study Type: Non-Intervention
Category:  Melanoma
Enrollment Status: Not Open to Enrollment

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Histopathologic Characteristics and Clinical Features of Nail Unit Squamous Cell Carcinoma: An Institutional Experience

Our goal is to facilitate the diagnosis of nail unit SCC, characterize its histologic and clinical features, and better understand patient outcomes, we will characterize the histopathologic changes of nail squamous cell carcinoma in a series of patients with a specific focus on the frequency of the finding of “atypical parakeratosis” in nail plate clippings and nail biopsies of histologically confirmed cases of nail unit SCC.

Study Type: Non-Intervention
Category: Squamous Cell Carcinoma
Enrollment Status: Not Open to Enrollment

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Revealing Accumulative Gene Mutations in Basal Cell Nevus Syndrome to Achieve Pathway-specific Therapies

The purpose of this study is to Identify the accumulative gene mutations in people with basal cell nevus syndrome with aging and sun exposure in order to better characterize their genotype for targeted specific therapies.

Study Type: Non-Intervention
Category: Basal Cell Carcinoma
Enrollment Status: Not Open to Enrollment

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A Phase 3B, Multicenter, Open-label Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects from 6 through 17 Years of Age with Moderate to Severe Plaque Psoriasis

The purpose of this research study is to test the long-term effects on child and adolescent psoriasis of an investigational (being tested) drug called apremilast, which is the same study drug the child received in the study he/she is about to complete or has just completed (CC-10004-PPSO-003).

Study Type: Intervention
Category: Inflammatory Skin Disorders
Enrollment Status: Not Open to Enrollment

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Vascular and Skin Eruptions Temporally Associated with COVID-19

During the COVID-19 pandemic, there has been an increase in number of children and young adults with painful red to purple lesions, blisters, and ulcers on the feet, toes and fingers around the world. The purpose of this research study is to understand if these skin changes are a sign of COVID-19 infection or a response to the virus.

Study Type: Non-Intervention
Category: COVID-19
Enrollment Status: Open to Enrollment

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Evaluation of Circulating Tumor Cells in Melanoma

The aim of this study is to develop and optimize a microfluidic immunosensor array method for detection and capture of intact melanoma CTC in patients diagnosed with primary melanoma.

Study Type: Non-Intervention
Category: Melanoma
Enrollment Status: Not Open to Enrollment

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Light treatment Effectiveness (LITE) Study

The purpose of this study is to compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based NB-UVB phototherapy for the treatment of psoriasis. Phototherapy delivered at home or the office are both common treatments for psoriasis, but it is not known how well they compare to one another.

Study Type: Intervention
Category: Psoriasis
Enrollment Status: Open to Enrollment

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USCLC National Cutaneous Lymphoma Registry

The primary goal of the USCLC is to establish a registry of patients with cutaneous lymphoma in the United States. This is particularly important as some of the types of cutaneous lymphoma are very rare and it is only with a collaborative effort across multiple institutions and sites that enough data can be generated on each of these types of cancer.

Study Type: Non-Intervention
Category: Cutaneous T-Cell Lymphoma
Enrollment Status: Open to Enrollment

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Multicenter Phenotype-Genotype Analysis of Vascular Anomalies and Related Syndromes

The purpose of this research study is to develop a better understanding of the cause and natural history of vascular anomalies and related syndromes. We are doing this study because we hope that by better understanding the cause we may be able to improve care for people who are affected by these anomalies and related syndromes.

Study Type: Non-Intervention
Category: Venous Malformations
Enrollment Status: Open to Enrollment

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Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

The purpose of this research study is to develop a better understanding of vascular stains and to improve the usual laser treatment for your vascular stain by using optical coherence tomography (OCT). We are doing this study because we hope that by better understanding vascular stains and using OCT, we may be able to improve care for people who are affected by these stains.

Study Type: Intervention
Category: Vascular Anomalies and Birthmarks
Enrollment Status: On Hold

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An Open-Label, Repeat-Application, Intra-Subject, Dose Escalation (Part 1) Followed by a Randomized, Double-Blind, Placebo-Controlled (Part 2) Trial of Topical VT30 in Subjects with Venous, Lymphatic or Mixed Malformations Associated with PIK3CA or TEK Genetic Mutations

The main purpose of the study is to find out the safety and tolerability of VT30 gel after multiple doses of topical administration in Venous Malformations (VM), Lymphatic Malformations (LM), and Venolymphatic Malformations (VLM) lesions of the skin.

Study Type: Intervention
Category: Vascular Anomalies and Birthmarks
Enrollment Status: Open to Enrollment

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FAS Apoptotic Pathway Abnormalities in Cutaneous T-Cell Lymphoma (Mycosis Fungiodes (MF) and Sezary Syndrome (SS))

The purpose of this research study is to learn how CTCL and related disorders develop and progress. We are doing this research because having a better understanding of CTCL may help us develop new diagnostic and treatment tools in the future to improve the management and prognosis of individuals suffering from CTCL.

Study Type: Non-Intervention
Category: Cutaneous T-Cell Lymphoma
Enrollment Status: Open to Enrollment

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Quantification of Formaldehyde in Textiles: Impact on Allergic Contact Dermatitis

The purpose of this research study is to determine the amount of formaldehyde in clothing that will cause allergic contact dermatitis in people allergic to formaldehyde. We are doing this research because approximately 10% of patients with contact dermatitis are allergic to formaldehyde and many of these patients are allergic to the formaldehyde found in clothing. Because the amount of formaldehyde in clothing that may cause an allergic reaction is unknown, this presents challenges to those who are allergic to formaldehyde when buying clothing. This research study will help us determine formaldehyde amounts in clothing and which of those amounts will most likely cause allergic reactions. Results from this study could provide researchers with information on how chemicals (formaldehyde) in clothing cause allergic contact dermatitis.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: On Hold

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Characterization of the Virome and Microbiome of Normal and Neoplastic Skin of Organ Transplant Recipients

The purpose of this research study is to look at the relationship between cutaneous human papillomaviruses and squamous cell carcinomas (SCC) in people who either have or have not had an organ transplant. We are doing this research because we would like to address if drugs which works against the body’s immune (protective) response, often used in organ transplant patients inclines them to HPV infections versus people who have not taken these drugs. Also, we would like to see if HPVs present in SCCs are the same as in normal skin.

Study Type: Non-Intervention
Category: Squamous Cell Carcinoma
Enrollment Status: Open to Enrollment

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Role of SIRT3 and PLK4 in Melanoma Development and Progression

The main purpose of this study is to collect and use a portion of the melanoma tissue removed during a standard of care biopsy or surgical removal. This would be residual tissue, which would normally be stored and kept with your medical records. This melanoma tissue collected will be used to do research on understanding how skin cells change and progress into melanoma.

Study Type: Non-Intervention
Category: Melanoma
Enrollment Status: Open to Enrollment

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Histologic Evaluation of Cutaneous SCC Debulk Specimens Prior to MMS for Accurate Staging and Biomarker Correlation

The main purpose of this study is to research on the current methods of grading skin cancer and how that relates to the long term health outcomes of patients with SCC including rates of metastasis (spread).

Study Type: Non-Intervention
Category: Squamous Cell Carcinoma
Enrollment Status: Open to Enrollment

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North American Contact Dermatitis Group Registry

The North American Contact Dermatitis Group (NACDG) collects data on patch test results in combination with basic occupational and clinical information for the detection of delayed type hypersensitivity reactions to topical allergens. The data is used to answer questions about most frequent contact allergens, trends related to allergens and occupation, relatively new allergen frequency of reaction, or allergens increasing in frequency of allergic reactions reported.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: Not Open to Enrollment

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Outcomes and Correlative Studies of Patch Testing in Dermatology

The purpose of this study is to examine patch test reactions to a variety of different allergens and to investigate reaction trends based on other clinical factors. The data will be used to provide physicians treating individuals with dermatitis information on how to improve the quality of care they provide through the UW Department of Dermatology.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: Not Open to Enrollment

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