Clinical Research

The University of Wisconsin Department of Dermatology conducts clinical research on a wide range of topics in both children and adults. Use the links below to jump to sections of our Clinical Research website.

Clinical Trials Actively Recruiting Patients

We are actively recruiting for the following clinical trials.

This list is not exhaustive – we are actively conducting other clinical trials as described later on this page. Only trials listed here have been approved for direct recruitment of patients via web postings.

Vascular and Skin Eruptions Temporally Associated with COVID-19

During the COVID-19 pandemic, there has been an increase in number of children and young adults with painful red to purple lesions, blisters, and ulcers on the feet, toes and fingers around the world. The purpose of this research study is to understand if these skin changes are a sign of COVID-19 infection or a response to the virus.

Study Type: Non-Intervention
Category: COVID-19
Enrollment Status: Open to Enrollment

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Donating up to 4 blood samples
  • Donating a spit sample
  • Collection of information from your medical record

Eligibility Criteria

Inclusion

  • Individual of any age from infant to adult
  • affected Patients: Diagnosed with a possible SARS-CoV-2 related vascular or skin eruption
  • Health Patients: Not diagnosed with or history of possible SARS-CoV-2 related vascular or skin eruption or COVID disease

Principal Investigator and Contact Information

Lisa Arkin, MD
Principal Investigator
Heather Neils
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Vascular-and-Skin-Eruptions-Temporally-Associated-with-COVID-19

USCLC National Cutaneous Lymphoma Registry

The primary goal of the USCLC is to establish a registry of patients with cutaneous lymphoma in the United States. This is particularly important as some of the types of cutaneous lymphoma are very rare and it is only with a collaborative effort across multiple institutions and sites that enough data can be generated on each of these types of cancer.

Study Type: Non-Intervention
Category: Cutaneous T-Cell Lymphoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Data collected from your medical record about your disease
  • Log into the registry to complete online questionnaires about how your disease affects your life

Eligibility Criteria

  • Diagnosis of Cutaneous Lymphoma

Principal Investigator and Contact Information

Gary S. Wood, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#USCLC-National-Cutaneous-Lymphoma-Registry

Back to top


The Impact of Pediatric Skin Disorders

The goal of this study is to understand the severity and the type of stigma experienced across different kinds of skin conditions and therefore help identify methods of intervention to lessen the impact of skin disorders.

Study Type: Non-Intervention
Category: Pediatric Dermatology
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Completion of a one-time questionnaire by parent and child

Eligibility Criteria

Inclusion

  • Subjects must be aged 8-17 years of age
  • Subject must be diagnosed with a chronic skin disease deemed to be severe enough and/or in a visible location that could be stigmatizing as determined by the study doctor
  • Subject and parent must both be English speaking with at least one parent/guardian who will complete the questionnaires
  • Subject and Parent/Guardian must be able to complete the relevant questionnaires

Exclusion

  • Children under 8 years of age
  • Children with developmental delay and/or a behavioral disorder that would preclude participation in form completion
  • Children with a non-cutaneous disorder that is considered by the Study doctor to be stigmatizing

Principal Investigator and Contact Information

Lisa Arkin, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Impact-of-Pediatric-Skin-Disorders

NIH ID

NCT03544866

Back to top


Multicenter Phenotype-Genotype Analysis of Vascular Anomalies and Related Syndromes

The purpose of this research study is to develop a better understanding of the cause and natural history of vascular anomalies and related syndromes. We are doing this study because we hope that by better understanding the cause we may be able to improve care for people who are affected by these anomalies and related syndromes.

Study Type: Non-Intervention
Category: Venous Malformations
Enrollment Status: Open to Enrollment

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Data collected from your medical record about your disease
  • Optional Skin Biopsy
  • Optional Blood Sample
  • Optional Spit Sample
  • Optional Cheek Swab
  • Optional donation of excess tissue collected from a surgery

Eligibility Criteria

  • Individual of any age from infant to adult
  • Diagnosed with a vascular anomaly or discrepancy of growth

Principal Investigator and Contact Information

Beth Drolet, MD. ChairBeth Drolet, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Multicenter-Phenotype-Genotype-Analysis

Back to top


An Open-Label, Single Blind Study of How Knowledge of Risk of Subsequent Basal Cell Carcinoma Affects Compliance with Requested Follow-Up in Patients with First Basal Cell Carcinoma

The purpose of this research study is to determine one-year compliance with requested follow-up after treatment for basal cell carcinoma. This research is being done because we think if patients are provided with a risk assessment of developing basal cell carcinoma in the future then compliance after initial treatment would improve.

Study Type: Non-Intervention
Category: Basal Cell Carcinoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Completion of a one-time risk assessment questionnaire and a follow-up phone call

Eligibility Criteria

Inclusion

  • 18 years of age or older
  • Diagnosed with at least one Basal Cell Carcinoma within 30 days prior to enrollment
  • Able and willing to answer all questions accurately in the Individualized Risk Assessment

Exclusion

  • History of Basal Cell Carcinoma 31 or more days prior to enrollment
  • Solid Organ Transplant Recipient
  • History of Immunodeficiency (e.g., HIV infection, AIDS, genetic immunodeficiency)

Principal Investigator and Contact Information

Robert Glinert, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Knowledge-of-Risk-of-Subsequent-Basal-Cell-Carcinoma

NIH ID

NCT04093401

Back to top


FAS Apoptotic Pathway Abnormalities in Cutaneous T-Cell Lymphoma (Mycosis Fungiodes (MF) and Sezary Syndrome (SS))

The purpose of this research study is to learn how CTCL and related disorders develop and progress. We are doing this research because having a better understanding of CTCL may help us develop new diagnostic and treatment tools in the future to improve the management and prognosis of individuals suffering from CTCL.

Study Type: Non-Intervention
Category: Cutaneous T-Cell Lymphoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Agreement for the research study to use left-over tissue from your standard-of-care biopsies
  • Optional Blood Sample

Eligibility Criteria

Inclusion

  • Individuals with cutaneous lymphoproliferative disorders (CLPDs) and potential precursor conditions like chronic dermatitis
  • Controls including inflammatory skin diseases (e.g. acute dermatitis, psoriasis, drug rashes, normal skin).

Exclusion

  • Women who are pregnant
  • Treatment within 2 weeks prior to biopsy

Principal Investigator and Contact Information

Gary S. Wood, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#FAS-Apoptotic-Pathway-Abnormalities-in-CTCL

Back to top


Therapeutic Targeting of Metabolic Adaptation to Metformin in Chronic Lymphocytic Leukemia (CLL)

The purpose of this research study is to determine how blood may react to different cancer therapy drugs. We are doing this research because we are looking for novel ways to better treat lymphocytic leukemia.

Study Type: Non-Intervention
Category: Chronic Lymphocytic Leukemia (CLL)
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • One-time blood sample

Eligibility Criteria

Inclusion

  • 18 years of age or older
  • Chronic Lymphocytic Leukemia (CLL) Stage I – III. Please call for details.

Exclusion

  • Evidence of T11, 14, and/or Cyclin D1 staining from flow cytometry results
  • Diagnosis of atypical CLL

Principal Investigator and Contact Information

Stefan Schieke, MD
Principal Investigator
Christina Sheehan
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2006

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Therapeutic-Targeting-of-Metabolic-Adaptation-to-Metformin-in-CLL

Back to top


Quantification of Formaldehyde in Textiles: Impact on Allergic Contact Dermatitis

The purpose of this research study is to determine the amount of formaldehyde in clothing that will cause allergic contact dermatitis in people allergic to formaldehyde. We are doing this research because approximately 10% of patients with contact dermatitis are allergic to formaldehyde and many of these patients are allergic to the formaldehyde found in clothing. Because the amount of formaldehyde in clothing that may cause an allergic reaction is unknown, this presents challenges to those who are allergic to formaldehyde when buying clothing. This research study will help us determine formaldehyde amounts in clothing and which of those amounts will most likely cause allergic reactions. Results from this study could provide researchers with information on how chemicals (formaldehyde) in clothing cause allergic contact dermatitis.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Patch testing with both Finn Chambers and fabric swatches over a period of a week

Eligibility Criteria

Inclusion

  • 18 years of age or older
  • Presented to UW Dermatology clinic within last 3 years
  • Patch tested with positive reaction to formaldehyde 2% aqueous (graded as 1,2, or 3 at > 96 hours after placement)
  • Currently symptom-free from allergic contact dermatitis
  • Not on any immunosuppressive medication which could interfere with interpretation of the patch testing

Exclusion

  • Women who are pregnant

Principal Investigator and Contact Information

Margo Reeder, MD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Quantification-of-Formaldehyde-in-Textiles

Back to top


Characterization of the Virome and Microbiome of Normal and Neoplastic Skin of Organ Transplant Recipients

The purpose of this research study is to look at the relationship between cutaneous human papillomaviruses and squamous cell carcinomas (SCC) in people who either have or have not had an organ transplant. We are doing this research because we would like to address if drugs which works against the body’s immune (protective) response, often used in organ transplant patients inclines them to HPV infections versus people who have not taken these drugs. Also, we would like to see if HPVs present in SCCs are the same as in normal skin.

Study Type: Non-Intervention
Category: Squamous Cell Carcinoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Willing to donate leftover tissue from the removal of your squamous cell carcinoma (SCC)

Eligibility Criteria

  • 18 years of age or older
  • Having SCC removed that is visible and palpable with a tumor size of at least 1cm

Principal Investigator and Contact Information

Gloria Xu, MD, PhD
Principal Investigator
photo of jennifer m tranJennifer Tran
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Virome-and-Microbiome-of-Skin-of-Organ-Transplant-Recipients

Back to top


Role of SIRT3 and PLK4 in Melanoma Development and Progression

The main purpose of this study is to collect and use a portion of the melanoma tissue removed during a standard of care biopsy or surgical removal. This would be residual tissue, which would normally be stored and kept with your medical records. This melanoma tissue collected will be used to do research on understanding how skin cells change and progress into melanoma.

Study Type: Non-Intervention
Category: Melanoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Participation in this study will consist of donating a portion of your standard-of-care skin biopsy/excision tissue sample.

Eligibility Criteria

  • 18 years of age or older
  • United States of America Veteran
  • Diagnosis of primary or metastatic melanoma
  • Undergoing a standard-of-care removal of subcutaneous melanoma tumor

Principal Investigator and Contact Information

Nihal Ahmad, PhD
Principal Investigator
Christina Sheehan
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2006

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#SIRT3-and-PLK4-in-Melanoma-Development-and-Progression

Back to top


Histologic Evaluation of Cutaneous SCC Debulk Specimens Prior to MMS for Accurate Staging and Biomarker Correlation

The main purpose of this study is to research on the current methods of grading skin cancer and how that relates to the long term health outcomes of patients with SCC including rates of metastasis (spread).

Study Type: Non-Intervention
Category: Squamous Cell Carcinoma
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

  • Participation in the research study involves the collection of information from your medical records regarding your skin cancer and will not require any additional time.
  • If tissue is sent to the pathology lab after removal of your SCC, we would also like your permission to use a small portion for our research on proteins that play a role in SCC.

Eligibility Criteria

  • 18 years of age or older
  • Undergoing a standard-of-care removal of SCC in a dermatology clinic

Principal Investigator and Contact Information

Gloria Xu, MD, PhD
Principal Investigator
Heather Neils
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Histologic-Evaluation-of-Cutaneous-SCC-Debulk-Specimens-Prior-to-MMS

Back to top


Wound Appearance and Effect on Patient Perception and Experience

The purpose of this study is to assess the effect of post-operative wound appearance on patient perception and experience.

Study Type: Non-Intervention
Category: Misc Dermatology
Enrollment Status: Open to Enrollment (enrollment paused due to COVID-19)

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Participation Includes

Completing a 5-10 minute survey

Eligibility Criteria

  • 18 years of age or older

Principal Investigator and Contact Information

Gloria Xu, MD, PhD
Principal Investigator
photo of jennifer m tranHeather Neils
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Wound-Appearance-and-Effect-on-Patient-Perception

Back to top


North American Contact Dermatitis Group Registry

The North American Contact Dermatitis Group (NACDG) collects data on patch test results in combination with basic occupational and clinical information for the detection of delayed type hypersensitivity reactions to topical allergens. The data is used to answer questions about most frequent contact allergens, trends related to allergens and occupation, relatively new allergen frequency of reaction, or allergens increasing in frequency of allergic reactions reported.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: Not Open to Enrollment

This is an accordion element with a series of buttons that open and close related content panels.

More Information

Principal Investigator and Contact Information

Margo Reeder, MD
Principal Investigator
Heather Neils
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#North-American-Contact-Dermatitis-Group-Registry

Back to top


Outcomes and Correlative Studies of Patch Testing in Dermatology

The purpose of this study is to examine patch test reactions to a variety of different allergens and to investigate reaction trends based on other clinical factors. The data will be used to provide physicians treating individuals with dermatitis information on how to improve the quality of care they provide through the UW Department of Dermatology.

Study Type: Non-Intervention
Category: Contact Dermatitis
Enrollment Status: Not Open to Enrollment

This is an accordion element with a series of buttons that open and close related content panels.

Principal Investigator and Contact Information

Margo Reeder, MD
Principal Investigator
Heather Neils
Primary Contact
clinicaltrials@dermatology.wisc.edu
(608) 287-2640

Direct Link to this Study

dermatology.wisc.edu/research/clinical-research/#Outcomes-and-Correlative-Studies-in-Patch-Testing

All Clinical Trials

Along with the Actively Recruiting clinical trials above, our current research efforts involve topics such as:

  • The relationship between skin patch testing results for allergic dermatitis and factors such as co-existing disease, medications, allergies, over-the-counter products, and clothing.
  • The development and treatment of cutaneous T cell lymphomas
  • The treatment of childhood and adult atopic dermatitis
  • The treatment of childhood psoriasis
  • The development and treatment of childhood morphea
  • The development and treatment of childhood discoid lupus
  • The impact of childhood skin disorders
  • Understanding the perceived utility of minimally invasive dermatologic care for gender affirmation procedures
  • The use of laser hair removal as a treatment for pilonidal disease
  • The relationship between human papillomavirus and skin cancer
  • The detection, development, and progression of melanoma
  • The development, treatment, and progression of squamous cell and basal cell carcinomas
  • The development of a human skin model for psoriasis
  • The relationship between the skin microbiome and skin disease

In addition, clinical faculty meet with basic science faculty and investigators from other disciplines to identify opportunities for translational research in areas such the molecular mechanism of cancer development and the molecular diagnosis of skin diseases.

Through the NIH-funded UW Skin Diseases Research Center (SDRC), the program offers funding for pilot and feasibility studies from young investigators, established dermatologic investigators embarking on new topics, and other established investigators entering skin diseases research.

Back to top

Contact

Heather Neils
Clinical Trials Admin.
Dept. of Dermatology
hneils@dermatology.wisc.edu
608-287-2640

Christina Sheehan
Clinical Trials Coord.
Dept. of Dermatology
csheehan@dermatology.wisc.edu
608-287-2006

Fax: 608-287-2693

Clinical Investigators

Lisa M. Arkin, MD

Assistant Professor and Director of Pediatric Dermatology

William Aughenbaugh, MD

Professor and Vice Chair of Education

Daniel Bennett, MD

Associate professor and Vice Chair for Clinical Affairs

Molly Hinshaw, MD

Associate Professor and Section Chief of Dermatopathology

Margo Reeder, MD

Assistant Professor and Director of Quality Improvement, UW Dermatology

Stefan M. Schieke, MD

Assistant Professor, Dermatology Research Laboratories

Gary Wood, MD

Professor and Founding Chair, Geneva F. and Sture Johnson Professor Emeritus

To Heal
To Educate
To Discover

Our Mission