Department of Veterans Affairs Merit Review
“Role of SIRT3 in melanoma development and progression”
The goal of this study is to test the hypothesis that SIRT3 plays a critical role in melanoma progression via modulating p53 signaling, Ku70-Bax interaction and/or cellular metabolic homeostasis.
NIH/NCI
“Role of SIRT1 in melanocyte biology and melanocyte transformation”
The goal of this project is to define the involvement and therapeutic relevance of class III histone deacetylase SIRT1 in melanoma development and progression.
NIH/NIAMS
“Role of Polo-like Kinase-1 in Melanocytic Transformation”
These studies will contribute to our understanding of the role of Plk1 and its interaction with B-Raf in melanocytic cells. The outcome of this study is expected to enhance our understanding of mechanism of melanocytic transformation via dissecting interaction between Plk1 and B-Raf. This knowledge will be useful in designing novel strategies against hyperproliferative melanocytic disorders, including melanomagenesis.
UWSDRC Pilot Program/ICTR
“Development of a novel synthetic model to study skin polarity”
The overall goal of this project is to develop an in vitro synthetic model of planar cell polarity (PCP) and use this model to dissect the mechanisms that regulate skin polarity.
Department of Veteran Affairs Merit Review
“Role of Notch Signaling in Melanoma Transdifferentiation and Tumor Progression”
The objective of this research is to better understand and exploit an intrinsic feature of melanoma that allows conversion of the rapidly dividing tumor cells into non-dividing ‘brain cell-like’ cells as potential new treatment for melanoma.
Department of Defense
“A Model for Understanding the Genetic Basis for Disparity in Prostate Cancer Risk”
The research proposed here is expected to identify mechanisms by which normal prostate cells become cancerous and therefore it can be considered basic at this time for immediate clinical applicability.
Chandra K. Singh (profile)
UWSDRC Pilot Program/ICTR
“Dietary Grape in the Management of Atopic Dermatitis.”
In this application, we propose to test the hypothesis that grape antioxidants, in its natural combination (grape powder), will inhibit development and progression of atopic dermatitis in NC/NgaTnd mice.