Minakshi Nihal, PhD
Position title: Senior Scientist III
Wood Laboratory Page
All Inquiries: Research and Administration
BS (Chemistry, Botany, & Zoology) 1985, University of Lucknow, India
MS (Chemistry) 1987, University of Lucknow, India
Diploma (Russian Language) 1991, University of Lucknow, India
PhD (Chemistry) 1992, University of Lucknow, India
1992-1994: Senior Research Fellowship, Industrial Toxicology Center, Lucknow, Council of Scientific and Industrial Research (India)
1988-1990: Junior Research Fellowship, Uttar Pradesh State Council of Science Technology (India)
I am specifically interested in understanding the biology of human melanoma and cutaneous T-cell lymphoma (CTCL). My interest is focused on the epigenetic silencing and interplay of death receptor-ligand partners, FAS and FASL genes in two types of CTCL: mycosis fungoides (MF) and the Sezary syndrome (SS). I am also involved in studying the role of PLK4 in melanoma as well as in CTCL.
Denu RA, Shabbir M, Nihal M, Singh CK, Longley BJ, Burkard ME, Ahmad N. Centriole overduplication is the predominant Mmechanism leading to centrosome amplification in melanoma. Mol Cancer Res.16, 517-527, 2018. PMID: 29330283.
Singh CK, Nihal M, Ahmad N. Histone Deacetylase Inhibitory Approaches for the Management of Osteoarthritis. Am J Pathol. 6, 10335-48 2016. PMID 27560709.
Nihal M, Wood GS. C-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus. Oncotarget. 7, 53869-53880, 2016. PMID 27472394.
George J, Nihal M, Singh CK, Zhong W, Liu X, Ahmad N. Pro-proliferative function of mitochondrial sirtuin deacetylase SIRT3 in human melanoma. JID, 136, 809-18, 2016. PMID 26743598.
Singh CK, Kaur S, George J, Nihal M, Pellitteri Hahn MC, Scarlett CO, Ahmad N. Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach. Oncotarget. 6, 10335-48, 2015. PMID: 25929337
Wilking MJ, Singh CK, Nihal M, Ndiaye MA, Ahmad N. Sirtuin deacetylases: A new target for melanoma management. Cell Cycle. 13, 2821-6, 2014. PMID 25486469.
Nihal M, Wu J, Wood GS. Methotrexate inhibits the viability of human melanoma cell lines and enhances Fas/Fas-ligand expression, apoptosis and response to interferon-alpha: rationale for its use in combination therapy. Arch Biochem Biophys. 563, 101-07, 2014. PMID 24862567.
Wilking M, Singh CK, Nihal M, Zhong W, Ahmad A. SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation. Submitted Arch Biochem Biophys. 563, 94-100, 2014. PMID 24751483.
Siddiqui IA, Bharali DJ, Nihal M, Adhami VM, Khan N, Chamcheu JC, Khan MI, Shabana S, Mousa SA, Mukhtar H. Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo. Nanomedicine. 10, 1619-26, 2014. PMID 24965756.
Ndiaye MA, Nihal M, Wood GS, Ahmad N. Skin, Reactive Oxygen Species, and Circadian Clocks. Antioxid Redox Signal. 20, 2982-96, 2014. PMID 24111846.