Gagan Chhabra, Phd

Position title: Scientist I


Picture of Gagan Chhabra, PhD

Research Laboratory
Ahmad Laboratory Page

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Ph.D. (Biotechnology) 2014; Jawaharlal Nehru University, New Delhi, India
MS (Biotechnology) 2006; Banaras Hindu University, Varanasi, India
BS (Zoology, Botany, Chemistry) 2003; CSJM University, Kanpur, India

Sep 2016 – June 2020: Postdoctoral Research Associate, University of Wisconsin, Department of Dermatology, Madison, WI, USA
Feb 2015 – Aug 2016: Postdoctoral Research Fellow, University of Illinois at Chicago, College of Medicine, Rockford, USA
2010 – 2014: Senior Research Fellow (Indian Council of Medical Research; ICMR), Jawaharlal Nehru University, New Delhi, India
2008-2010: Senior Research Fellow, National Institute of Immunology, New Delhi, India
2006-2008: Junior Research Fellow, National Institute of Immunology, New Delhi, India

Curriculum Vitae (PDF)

PubMed Publications (external link)

Research Interests
My research focuses on identifying new therapeutic targets and their mechanisms against skin cancer, especially melanoma. I am also interested in pre-clinical evaluation of novel combination therapeutics for melanoma management such as combination of targeted therapy with immunotherapy.

Recent Publications

Chhabra G, Singh CK, Ndiaye MA, Su S, Shirley CA, Ahmad N. Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma. NPJ Precis Oncol. 2024 Jan 6;8(1):6. PMID: 38184733; PMCID: PMC10771520.

Chhabra G, Ahmad N. Molecular chaos under the skin: Epigenetic reprogramming in hidradenitis suppurativa. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2319797121. Epub 2023 Dec 26. PMID: 38147564; PMCID: PMC10769847.

Chhabra G, Li WQ, Pameijer C. Editorial: Prognostic gene signatures in skin cancer. Front Oncol. 2023 May 3;13:1163642. PMID: 37207145; PMCID: PMC10189106.

Singh CK, Mintie CA, Ndiaye MA, Chhabra G, Roy S, Sullivan R, Longley BJ, Schieke SM, Ahmad N. Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC/NgaTndCrlj mice. Front Immunol. 2023 Jan 19;13:1051472. PMID: 36741360; PMCID: PMC9893861.

Suleman S, Chhabra G, Raza R, Hamid A, Qureshi JA, Ahmad N. Association of CARD14 Single-Nucleotide Polymorphisms with Psoriasis. Int J Mol Sci. 2022 Aug 19;23(16):9336. PMID: 36012602; PMCID: PMC9409305.

Chhabra G, Ahmad N. Trichloroisocyanuric Acid, A Swimming Pool Disinfectant: New Developments and Role in UV-Induced Skin Inflammation. Photochem Photobiol. 2023 Mar;99(2):869-871. Epub 2022 Sep 3. PMID: 36004539.

Raza R, Chhabra G, Bilal M, Ndiaye MA, Liaqat K, Nawaz S, Sgro JY, Rayment I, Ahmad W, Ahmad N. A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies. J Invest Dermatol. 2023 Jan;143(1):173-176.e3. Epub 2022 Aug 1. PMID: 35926655.

Thornton J, Chhabra G, Singh CK, Guzmán-Pérez G, Shirley CA, Ahmad N. Mechanisms of Immunotherapy Resistance in Cutaneous Melanoma: Recognizing a Shapeshifter. Front Oncol. 2022 Apr 19;12:880876. PMID: 35515106; PMCID: PMC9066268.

Su S, Chhabra G, Singh CK, Ndiaye MA, Ahmad N. PLK1 inhibition-based combination therapies for cancer management. Transl Oncol. 2022 Feb;16:101332. Epub 2021 Dec 29. PMID: 34973570; PMCID: PMC8728518.

Chhabra G, Ahmad N. BRAF Inhibitors in Melanoma Management: When Friends Become Foes. J Invest Dermatol. 2022 May;142(5):1256-1259. Epub 2021 Dec 3. PMID: 34872726; PMCID: PMC9199497.

Chhabra G, Singh CK, Guzmán-Pérez G, Ndiaye MA, Iczkowski KA, Ahmad N. Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in Braf C600E/Pten Null Mice. J Invest Dermatol. 2022 Apr;142(4):1145-1157.e7. Epub 2021 Sep 29. PMID: 34597611; PMCID: PMC9199498.

Singh CK, Chhabra G, Patel A, Chang H, Ahmad N. Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management. Nutrients. 2021 May 30;13(6):1867. PMID: 34070833; PMCID: PMC8226978.

Singh CK, George J, Chhabra G, Nihal M, Chang H, Ahmad N. Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma. Front Oncol. 2021 Apr 16;11:676077. PMID: 33937086; PMCID: PMC8085490.

Chhabra G, Singh CK, Amiri D, Akula N, Ahmad N. Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment. Molecules. 2021 Mar 3;26(5):1343. PMID: 33802331; PMCID: PMC7959117.

Schmuck EG, Roy S, Dhillon A, Walker S, Spinali K, Colevas S, Zhou T, Chhabra G, Liu Y, Kader Sagar MA, Childs CJ, Kink JA, Eliceiri KW, Hematti P, Raval AN. Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix. Exp Cell Res. 2021 Feb 15;399(2):112489. Epub 2021 Jan 14. PMID: 33453237.

Garvey DR, Chhabra G, Ndiaye MA, Ahmad N. Role of Polo-Like Kinase 4 (PLK4) in Epithelial Cancers and Recent Progress in its Small Molecule Targeting for Cancer Management. Mol Cancer Ther. 2021 Apr;20(4):632-640. Epub 2021 Jan 5. PMID: 33402398; PMCID: PMC8026525.

Su S, Chhabra G, Ndiaye MA, Singh CK, Ye T, Huang W, Dewey CN, Setaluri V, Ahmad N. PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. Mol Cancer Ther. 2021 Jan;20(1):161-172. Epub 2020 Nov 11. PMID: 33177155; PMCID: PMC7790869.


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