Gagan Chhabra, Phd

Position title: Scientist I


Picture of Gagan Chhabra, PhD

Research Laboratory
Ahmad Laboratory Page

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Ph.D. (Biotechnology) 2014; Jawaharlal Nehru University, New Delhi, India
MS (Biotechnology) 2006; Banaras Hindu University, Varanasi, India
BS (Zoology, Botany, Chemistry) 2003; CSJM University, Kanpur, India

Sep 2016 – June 2020: Postdoctoral Research Associate, University of Wisconsin, Department of Dermatology, Madison, WI, USA
Feb 2015 – Aug 2016: Postdoctoral Research Fellow, University of Illinois at Chicago, College of Medicine, Rockford, USA
2010 – 2014: Senior Research Fellow (Indian Council of Medical Research; ICMR), Jawaharlal Nehru University, New Delhi, India
2008-2010: Senior Research Fellow, National Institute of Immunology, New Delhi, India
2006-2008: Junior Research Fellow, National Institute of Immunology, New Delhi, India

Curriculum Vitae (PDF)

PubMed Publications (external link)

Research Interests
My research focuses on identifying new therapeutic targets and their mechanisms against skin cancer, especially melanoma. I am also interested in pre-clinical evaluation of novel combination therapeutics for melanoma management such as combination of targeted therapy with immunotherapy.

Recent Publications
Chhabra G, Singh CK, Amiri D, Akula N, Ahmad N. Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment. Molecules. 2021; 26(5):1343.

Su S*, Chhabra G*, Ndiaye MA, Singh CK, Ye T, Huang W, Dewey CN, Setaluri V, Ahmad N. PLK1 and NOTCH Positively Correlate in Melanoma and their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways. Mol Cancer Ther. 2021; 20(1):161-172. (*Equal first authorship).

Garvey DR*, Chhabra G*, Ndiaye MA*, Ahmad N. Role of polo-like kinase 4 (PLK4) in epithelial cancers and recent progress in its small molecule targeting for cancer management. Mol Cancer Ther. 2021; 20(4):632-640 (*Equal first authorship).

Singh CK, George J, Chhabra G, Nihal M, Chang H, Ahmad N. Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma. Front Oncol. 2021; 11:676077.

Singh CK, Chhabra G, Patel A, Chang H, Ahmad N. Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management. Nutrients. 2021; 13(6):1867

Singh CK, Chhabra G, Ndiaye MA, Siddiqui IA, Panackal JE, Mintie CA, Ahmad N. Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers (Basel). 2020; 12(8):2141.

Garcia-Peterson LM, Ndiaye MA, Chhabra G, Singh CK, Guzmán-Pérez G, Iczkowski KA, Ahmad N. CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Anti-proliferative Response in Human Melanoma Cells in vitro and in vivo. Photochem Photobiol. 2020.

Singh CK, Mintie CA, Ndiaye MA, Chhabra G, Dakup PP, Ye T, Yu M, Ahmad N. Chemoprotective effects of dietary grape powder on ultraviolet B radiation-mediated skin carcinogenesis in SKH-1 hairless mice. J Invest Dermatol. 2019; 139(3):552-561.

Chhabra G, Garvey DR, Singh CK, Mintie CA, Ahmad N. Effects and Mechanism of Nicotinamide Against UVA- and/or UVB-mediated DNA Damages in Normal Melanocytes. Photochem Photobiol. 2019; 95(1):331-337.

Chhabra G, Singh CK, Ndiaye MA, Fedorowicz S, Molot A, Ahmad N. Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications. Cancer Lett. 2018; 422:9-18.

Chhabra G, Wojdyla L, Frakes M, Ivancich M, Vinay P, Schrank Z, Ramirez BE, Puri N. Mechanism of Action of G-quadruplex Forming Oligonucleotide Homologous to the Telomere Overhang in Melanoma. J Invest Dermatol. 2018; 138(4):903-910.

Chhabra G, Ndiaye MA, Garcia-Peterson LM, Ahmad N. Melanoma Chemoprevention: Current Status and Future Prospects. Photochem Photobiol. 2017; 93(4):975-989.

Singh CK, Chhabra G, Ndiaye MA, Garcia-Peterson LM, Mack NJ, Ahmad N. The Role of Sirtuins in Antioxidant and Redox Signaling. Antioxid Redox Signal. 2018; 28(8):643-661.

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